Creation of Novel Biomaterials Using Coacervate Encapsulating Ultrafine Bubbles at High Density

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K04752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 27010:Transport phenomena and unit operations-related
• Research Institution: Kagoshima University
• Principal Investigator: Goshima Takashi 鹿児島大学, 理工学域工学系, 助教 (90709560)
• Co-Investigator(Kenkyū-buntansha): 二井 晋 鹿児島大学, 理工学域工学系, 教授 (90262865) ; 武井 孝行 鹿児島大学, 理工学域工学系, 教授 (90468059)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: サイクロン / ファインバブル / 複合コアセルベート / 核形成時間 / ガスカラム / 凝集 / 崩壊

Outline of Final Research Achievements

We have undertaken the synthesis of biocompatible materials with unique interfacial and structural characteristics derived from fine bubble (FB) technology as an advanced application of this technology. We selected a gelatin-arabic gum-based composite core-shell bead and designed a swirling flow mini-channel device with a porous membrane installed at the center of the lower part and an outlet tube. Supplying CO2 to the porous membrane promoted local pH reduction around the FB and bubble refinement. When HCl aqueous solution was added below the porous membrane, high-density fiber-like coacervate containing FBs with an average diameter of 29 μm were formed. On the other hand, adding HCl aqueous solution at the lower end of the outlet tube resulted in the formation of hollow particle-like coacervate with an average diameter of 5.8 μm and a coefficient of variation (CV) of 26.3%, indicating fine and highly monodisperse characteristics.

Free Research Field

気泡工学

Academic Significance and Societal Importance of the Research Achievements

高密度ウルトラファインバブル(UFB)のコアセルベートをつくることができれば、UFBは高い指向性と吸着性や圧壊による有価物分解能を有することで治療の利便性や患者QOLの向上に寄与するDDS製剤の開発やUFB群が連結して大きな比表面積と凹凸構造を有した空間が形成され細胞の新たな生体機能を発現する細胞ゲルファイバーの開発など波及効果が期待でき、医薬・医療の分野でのインパクトは大きい。