Total synthesis of (+)-spirotenuipesine A and repair of nerve function by dual activation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Tokushima Bunri University
• Principal Investigator: Imagawa Hiroshi 徳島文理大学, 薬学部, 教授 (80279116)
• Co-Investigator(Kenkyū-buntansha): 松井 敦聡 岐阜医療科学大学, 薬学部, 准教授 (60309698)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ネオビブサニン / スピロテヌイペシンA / 神経突起伸長作用 / 神経機能修復

Outline of Final Research Achievements

When the activity of spirotenuipesine A was measured in the presence of anti-NGF antibody, the activity was unaffected. These results suggest that the NGF-like active substance secreted from glial cells by spirotenuipesine A is not NGF itself. Moreover, since neovibsanins enhance the function of NGF, the activity of spirotenuipesine A was measured in the presence of neovibsanins, and no enhancement effect of spirotenuipesine A on the activity was observed. These results suggest that spirotenuipesine A promotes the production of neurotrophic factor-like active substances that are distinct from NGF.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

今回得られた研究成果は、スピロテヌイペシンAが、グリア細胞から分泌を促進する、神経栄養因子様物質を特定するために、重要な知見を与えたと考えられる。これまで未知であった、神経栄養因子様化合物が同定されれば、その機序解明に大きく貢献できる。また構造活性相関研究の成果は、損傷を受けた神経の再生を基盤とした、アルツハイマー病を始めとする神経変性疾患の治療シーズ開発に重要な知見を与えるものと考えられ、活性を持つが構造が単純で、化学合成による供給が容易な、新規な治療薬候補分子のデザインに繋がると考えられる。