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2023 Fiscal Year Final Research Report

Generation of radical species by the design of sulfonyl groups

Research Project

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Project/Area Number 21K05068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 33020:Synthetic organic chemistry-related
Research InstitutionNagoya University

Principal Investigator

Nambo Masakazu  名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 (10705528)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywordsラジカル種 / スルホニル基 / 炭素-スルホニル結合活性化 / スルホン / 分子触媒 / フォトレドックス触媒 / 1電子還元
Outline of Final Research Achievements

We developed a new method for reductive activation of alkyl sulfones to generate synthetically useful alkyl radical under mild conditions. By utilizing this method, we succeeded in applying it to radical transformations such as the Giese reaction. It was found that not only the choice of single-electron reducing agent but also the substituent on the sulfonyl group is extremely important in the generation of radical species.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究を通じ、スルホニル基の分子設計によってスルホンが有用なラジカル種前駆体として機能することを明らかにした。この知見を活用することで、新しい形式のラジカル分子変換の開拓が期待される。

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Published: 2025-01-30  

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