2023 Fiscal Year Final Research Report
Study on anti-obesity effects of Curcuma zedoaria and its effects on diet-induced obesity in mice
| Project/Area Number |
21K05478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Hyogo University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ガジュツ / Curcuma zedoaria / ウコン / 3T3-L1 / 肥満 / 糖尿病 / 生活習慣病 / 食品機能化学 |
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| Outline of Final Research Achievements |
In recent years, there has been a focus on effective prevention and improvement of lifestyle-related diseases through daily dietary habits.
The rhizomes of turmeric plants have been used in cooking and traditional medicine. Curcuma longa ("Akiukon" in Japanene) is a well-known turmeric plant with bright orange rhizomes and has been widely studied for its beneficial effects on health. On the other hand, C. zedoaria ("Gajutsu" or "Murasakiukon" in Japanene) is a characteristic turmeric plant, its beneficial effects on health had been little investigated. In this study, we investigated the beneficial effects of Gajutsu for lifestyle-related diseases using various experiments.
The results of the study using adipocyte model cells showed that Gajutsu increased the secretion of adiponectin, a bioactive substance that has a preventive effect against lifestyle-related diseases.
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| Free Research Field |
食品機能化学
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| Academic Significance and Societal Importance of the Research Achievements |
ガジュツは生活習慣病を予防・改善する有用な食材になりうるのかという点で研究を進め、上述したアディポネクチンの分泌増加作用を見出した。このことは、多くの生活習慣病またはその根源にある炎症、インスリン抵抗性に対し、ガジュツが有用である可能性を示したものである。ウコン属植物ガジュツの活用の提案は、各個人の状態に最適化した栄養の提案と実行“プレシジョン栄養”に新たな選択肢を与え、その社会実装や健康社会の実現につながるものと考えている。また、本研究成果はこの先にあるヒトにおける有用性、各種疾患モデル動物を用いた検討の際の重要な基礎資料となる。
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