2023 Fiscal Year Final Research Report
Innovative meat production technology by regulating the expression of insulin-like growth factor binding protein genes
| Project/Area Number |
21K05892
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 42010:Animal production science-related
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | IGF / 食肉 / 骨格筋 |
|---|
| Outline of Final Research Achievements |
To clarify the role of insulin-like growth factor binding proteins (IGFBPs) in chicken skeletal muscles and white adipose tissue, the regulatory mechanisms of gene expression of IGFBPs in vivo and in vitro (primary cultured chicken myotubes) and the factors involved in the mechanisms were investigated. The results suggest that all IGFBPs may have physiological roles in skeletal muscle, whereas IGFBPs do not play important roles in the adipose tissue. It was also shown that IGFBP-1 may affect the function of IGF-1, and that certain fatty acids and glucocorticoids are involved in the regulation of IGFBP-2-5 gene expression. Differences in responsiveness in IGFBP-2-5 gene expression regulatory mechanisms may be involved in skeletal muscle development in meat type chickens.
|
| Free Research Field |
栄養代謝学
|
| Academic Significance and Societal Importance of the Research Achievements |
食肉の消費量は20世紀に激増し、今後もアジアを中心とした国々では経済発展に伴い食肉、特に鶏肉の消費量が増加することが予想されている。それ故、肉用鶏の骨格筋量を決定づける骨格筋におけるタンパク質代謝調節機構を解明することには極めて重要な意義がある。本研究において、我々はニワトリの骨格筋において発現するIGFBPsが、骨格筋形成に関与することを示唆し、その制御因子の一部を明らかにしたたことから、その学術的意義は高い。また、今後明らかにされるであろう各IGFBPの生理的重要性の解明は、肉用鶏の生産性を高めるための飼養管理技術の向上に貢献すると判断され、高い社会的意義を有するものといえる。
|
