Prediction of mastitis using antimicrobial components.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K05893
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42010:Animal production science-related
• Research Institution: Hiroshima University
• Principal Investigator: Isobe Naoki 広島大学, 統合生命科学研究科(生), 教授 (80284230)
• Co-Investigator(Kenkyū-buntansha): 久枝 啓一 岡山理科大学, 獣医学部, 准教授 (20844781) ; 新居 隆浩 広島大学, 統合生命科学研究科(生), 准教授 (90804873)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 乳房炎 / ウシ / 抗菌物質

Outline of Final Research Achievements

We had the idea that a lack of antimicrobial substances in the udder would cause susceptibility to mastitis, and aimed to develop a mastitis prediction and prevention system focusing on these substances. It was found that higher concentrations of antimicrobial substances in milk during non-infection condition were associated with less susceptibility to mastitis. In addition, as a result of exploring methods to enhance immunity in animals susceptible to mastitis, the concentration of antimicrobial substances in milk was increased by stopping milking for three days or by vaccination. The results of this study have led to the development of a method for predicting mastitis and immune enhancement.

Free Research Field

家畜生産生理学

Academic Significance and Societal Importance of the Research Achievements

乳房炎による被害は甚大（年800億円以上）であるが、予防法や治療法は完全ではない。本研究で開発できた乳房炎予知法により、通常の牛乳を用いて分析しておけば、かかりやすいウシが判明し、そのウシのみに注意を払えばいいので、著しい省力化につながる。また、開発された2種類の乳房免疫力強化法により、乳房炎にかかりやすいウシをかかりにくくすることが可能となり、上記乳房炎予知の後のフォローアップとなりうる。この手法を用いれば抗生物質の削減も期待できる。