2023 Fiscal Year Final Research Report
New perspective on mitochondrial morphology regulation focusing on nucleoid dynamics
| Project/Area Number |
21K06066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 43030:Functional biochemistry-related
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| Research Institution | Shimane University (2023)
Osaka University (2021-2022) |
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Principal Investigator |
ISHIHARA Takaya 島根大学, 学術研究院医学・看護学系, 准教授 (70611862)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | mtDNA / ミトコンドリア核様体 / ダイナミクス / 膜ダイナミクス |
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| Outline of Final Research Achievements |
This research focused on the nucleoid structure and mitochondrial membrane dynamics based on our concept that "the distribution and arrangement of the nucleoid, which structure formed by the mitochondrial genome (mtDNA), is linked to the fission control mechanism of the mitochondrial membrane." Therefore, we approached to clarify the mechanism controlling mitochondrial morphology through molecular insights into the aspect of nucleoid structure and its regulations. During this research period, we analyzed ATAD3 as a molecule that controls the trafficking of the nucleoid and were able to realize a new mechanism from the perspective of the nucleoid regarding the control of mitochondrial dynamics and maintenance of its function.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
ミトコンドリアが分裂と融合によってダイナミックに形態を変化させる動的な特性は、酵母から哺乳動物まで種を超えて普遍的な制御機構を持つ。また、近年の研究から、この特性は分化や細胞応答などさまざまな高次の生命機能を維持するのに重要な機能を持つことが明らかになっている。本研究で得られた知見は、核様体の動きを制御する分子を起点とし、ミトコンドリアの形態や活性制御機構を明らかにしたものである。今後は同様のコンセプトによって、広くミトコンドリアの機能を改善させる分子詳細の解明に貢献できるものである。
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