2023 Fiscal Year Final Research Report
Molecular dynamics simulation for the destruction mechanism of amyloid fibrils by laser irradiation
| Project/Area Number |
21K06118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 43040:Biophysics-related
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| Research Institution | National Institutes of Natural Sciences |
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Principal Investigator |
Okumura Hisashi 大学共同利用機関法人自然科学研究機構(機構直轄研究施設), 生命創成探究センター, 准教授 (80360337)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 分子動力学シミュレーション / アミロイド線維 / 赤外線レーザー |
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| Outline of Final Research Achievements |
Proteins fold properly and perform essential functions for life. However, they sometimes aggregate and cause several diseases. Attempts are being made to destroy these protein aggregates by irradiating them with infrared free-electron lasers, leading to the development of new therapeutic methods. However, the mechanism by which protein aggregates are destroyed by laser irradiation has not been understood. In this study, the mechanism was elucidated by computer simulation. I also clarified which protein aggregates are easily destroyed and which protein aggregates are not easily destroyed.
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| Free Research Field |
理論生物物理学
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| Academic Significance and Societal Importance of the Research Achievements |
タンパク質凝集体の引き起こす病気にはアルツハイマー病やハンチントン病、パーキンソン病など治療法が確立していない病気が多い。これらの大半の病気には対処療法しかなく、その原因を直接取り除く方法はない。赤外線レーザーを照射する方法は病気の原因に直接アタックするので、この方法が実用に至れば意義は大きい。これまでレーザー照射により病気の原因物質を除去できることは実験的に知られていたが、その理由は不明であった。これを明らかにしたのが本研究である。本研究により将来、治療に使えるかもしれない手法の理論的裏付けを与えることができた。
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