2023 Fiscal Year Final Research Report
Genome DNA dynamics in the transition from vegetative to reproductive growth stages
| Project/Area Number |
21K06225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 44030:Plant molecular biology and physiology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
阿部 光知 東京大学, 大学院総合文化研究科, 教授 (20343238)
都筑 正行 高知大学, 総合科学系生命環境医学部門, 講師 (40845616)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 成長期変換 / マイクロRNA / プロセッシング / シロイヌナズナ |
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| Outline of Final Research Achievements |
Plants show two different growing processes: vegetative growth, which is the process of enlarging the body, and reproductive growth, which is the process of producing reproductive cells for the next generation. It is important to regulate the timing of reproductive growth from vegetative growth in order to ensure that plants can survive and produce offspring in response to environmental changes. The molecular switch mechanism of gene expression is important for this process, and there are many unknowns about the molecular level switching mechanism. This study revealed that the sites where microRNAs, which are regulators of expression, are formed (undergo processing) are quite scattered in the nucleus. Previous reports suggested that microRNAs are localized in a few granular structures in the nuclei, but the present study clearly showed that such results of preceding reports need to be reexamined in a condition as natural as possible.
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| Free Research Field |
植物分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
植物は動きがないという見方から、細胞内のダイナミクスや自分の遺伝子の発現は非常に緩慢であるように思われている傾向がある。しかし個体としては動けないが、植物の細胞レベルや自らの遺伝子の発現調節ということに目を向けると、非常にダイナミックに活動をしていることがわかる。植物細胞内で環境応答や発生の過程で見せる遺伝子発現の切り替え機構を知るには、研究解析のためであっても本来植物が行なっている状況に近づける必要があり、研究対象としたい一つのタンパク質に注目するあまり、過剰に細胞内で作らせると、細胞内で本来と異なる挙動を示す可能性が明らかとなった。
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