Establishment of mouse embryonic imaging system for vascular development

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 44040:Morphology and anatomical structure-related
• Research Institution: Osaka University
• Principal Investigator: UCHIDA Yutaka 大阪大学, 大学院生命機能研究科, 助教 (50833787)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: マウス胚 in vivo イメージング系 / 血管リモデリング

Outline of Final Research Achievements

The hierarchical and beautiful branching patterning of the vascular system forms through vascular remodeling. Elucidating the mechanism of vascular remodeling is essential for vascular biology research. Because the essence of vascular remodeling is the “movement” of vascular endothelial cells, to reveal when, where, and how vascular endothelial cells move is essential for understanding the mechanism of vascular remodeling. Therefore, in order to clarify the essence of vascular remodeling, this research project established the embryonic vasculature imaging system using two-photon excitation microscopy.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

本研究で確立を試みた二光子励起顕微鏡を用いたマウス胎児のin vivoイメージング系は、血管系の発生のみならず発生にかかわる多くの現象を可視化することが可能であり、発生過程においてその構造が大きく変化する現象における多くの議論にその答えを出すことが可能である。したがって、発生生物学の分野に果たす学術的意義は大きいと考えている。