2023 Fiscal Year Final Research Report
Regulatory mechanisms of vascular remodeling after ischemic stroke
| Project/Area Number |
21K06406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46020:Anatomy and histopathology of nervous system-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 脳梗塞 / 血管 / 中大脳動脈閉塞 / 虚血 |
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| Outline of Final Research Achievements |
Ischemic stroke triggers vascular remodeling, including blood-brain barrier breakdown and angiogenesis, but the regulatory mechanisms remain unclear. In this study, we revealed spatiotemporal changes in vascular properties and the emergence of novel ischemia-inducible cell population after stroke by gene expression analysis and visualization of vascular receptors and stress response in a mouse model of cerebral ischemia. The study also showed the potential to control stroke pathology by intervening in specific signaling pathways and cell populations.
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| Free Research Field |
神経解剖学
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| Academic Significance and Societal Importance of the Research Achievements |
脳血管障害は、死亡、要介護の主要な原因の１つであり、この脳血管障害の大半が脳梗塞である。現状の脳梗塞の治療は、急性期に限られごく一部の患者にしか適用されておらず、新たな治療法の開発が待ち望まれている。本研究では、脳梗塞後の血管特性の変化、および脳梗塞病態を制御する分子機構の一端を明らかにすることができた。本研究成果が、脳梗塞の新たな治療戦略の開発に貢献することが期待される。
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