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2023 Fiscal Year Final Research Report

The role of ER stress proteins for mast cell functions

Research Project

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Project/Area Number 21K06577
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47040:Pharmacology-related
Research InstitutionHiroshima University

Principal Investigator

Koichiro Ozawa  広島大学, 医系科学研究科(薬), 教授 (10211822)

Co-Investigator(Kenkyū-buntansha) 細井 徹  山陽小野田市立山口東京理科大学, 薬学部, 教授 (40379889)
柳瀬 雄輝  広島大学, 医系科学研究科(薬), 准教授 (40452586)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords小胞体ストレス / アレルギー / マスト細胞
Outline of Final Research Achievements

The number of patients suffering from immediate-type allergies is increasing in the world. However, the effects of conventional drugs of immediate-type allergies, such as H1 anti-histamine, are insufficient The endoplasmic reticulum is an important intracellular organ for the activation of mast cells and basophils. However, the relationship between endoplasmic reticulum stress sensor proteins and the functions of mast cells and basophils has been unclear. Therefore, we here investigated the role of between endoplasmic reticulum stress proteins in the activation of mast cells and basophils.

Free Research Field

臨床薬理学

Academic Significance and Societal Importance of the Research Achievements

即時型アレルギーを罹患する患者は国内外で増加傾向であるが、既存の治療薬では不十分であることが多いため、新しい抗アレルギー薬の開発が求められている。本研究ではマスト細胞・好塩基球における小胞体ストレスセンサタンパクの役割を解明することで、従来と異なる物質を標的とする新しいアレルギー治療薬の開発に貢献する。

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Published: 2025-01-30  

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