2023 Fiscal Year Final Research Report
Establishment of a novel treatment strategy for retinal degenerative diseases by the spatial and temporal control of the inflammatory reactions
| Project/Area Number |
21K06605
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 47040:Pharmacology-related
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | 薬理学 / 網膜 / 神経変性疾患 / 緑内障 / 網膜色素変性 |
|---|
| Outline of Final Research Achievements |
In the present study, I hypothesize that the inflammatory reaction are at least in part involved in progress of retinal neuronal cell death induced by retinal degenerative diseases, such as glaucoma and retinitis pigmentosa. The present study demonstrated that stimulation of TLR9, which is though to evoke the inflammatory responses, induced protective effects on the retinal ganglion cells in the retinas of glaucoma model mice, and that TNF-alpha originated from Muller cells was involved in the underlying mechanisms. retinitis pigmentosa model mice were comprehensively analyzed. In addition, the present study showed that stimulation of TLR9 and cannabinoid CB2 receptor induced weak protective effects on photoreceptor cells in the retinas of the retinitis pigmentosa model mice.
|
| Free Research Field |
薬理学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究では，網膜神経変性の発症と炎症性反応との間の関係を明らかにすることによって，網膜変性疾患に随伴する網膜神経細胞死の発症やその抑制の鍵となる分子を推測・実証するための基礎を得ることができた．今後，本研究で得られた研究成果は，緑内障や網膜色素変性をはじめとする網膜変性疾患に対する神経保護治療法の開発に繋がることが期待される．これらの疾患に対する神経保護薬の開発は未だ実現していない現状において，本研究の成果の学術的および社会的意義は大であると考えられる．
|
