2023 Fiscal Year Final Research Report
Analysis of cancer elongation system by prosaposin secreted by tumor-associated macrophages
| Project/Area Number |
21K06736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48010:Anatomy-related
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| Research Institution | Matsuyama University (2022-2023)
Ehime University (2021) |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | プロサポシン / 腫瘍随伴マクロファージ / 癌進展 / ソルチリン / mRNA / 大腸癌 |
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| Outline of Final Research Achievements |
When nerves are damaged, a protein called prosaposin increases and protects the damaged nerves. On the other hand, it has been found that when cancer cells spread, cells near the cancer release prosaposin, which the cancer cells receive. This indicates that when cancer cells spread, they take in prosaposin like nutrients. For example, in the case of cerebral infarction, prosaposin has a positive effect on damaged nerves. On the other hand, in the case of colon cancer, prosaposin becomes a nutrient for the cancer, which has a negative effect on the body. Therefore, if we could freely switch between secreting and stopping prosaposin, it could become a new cancer treatment method.
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| Free Research Field |
分子細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
プロサポシンはもともと体の中にある物質です。プロサポシンには体にいい効果もあり、全身のプロサポシンを減少させてしまうと副作用が出てしまいます。そこで、がんのまわりだけプロサポシンを減らせるという新しいがん治療方法を開発しています。プロサポシンを細胞の中で分解させることで、周囲のがん細胞に栄養を与えないという治療方法です。栄養が足りなくなったがんは伸びるのをやめます。
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