Possible roles of human mast cells in the formation of xanthelasma palpebrarum

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K06909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Iwate Medical University
• Principal Investigator: Kataoka Tatsuki 岩手医科大学, 医学部, 教授 (20343254)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: マスト細胞 / 皮膚黄色腫 / ICAM1 / 泡沫細胞

Outline of Final Research Achievements

In this study, we found that mast cells surround the accumulated foam cells, suggesting their involvement in xanthoma formation. Coculture of THP-1 or U937 monocytes with the human mast cell line LUVA upregulated their uptake of oxLDL. Positive staining for intracellular cell adhesion molecule-1 (ICAM-1) at the borders between mast cells and foam cells was seen in pathological specimens of the most common cutaneous xanthoma, xanthelasma palpebrarum, and in cocultures. In the latter, ICAM1 mRNA levels were upregulated. The administration of anti-ICAM-1 blocking antibody inhibited the increase in oxLDL uptake by THP-1 or U937 monocytes cocultured with LUVA. Taken together, these results suggest a role for mast cells in the formation of xanthelasma palpebrarum and the involvement of ICAM-1 in this process.

Free Research Field

人体病理学

Academic Significance and Societal Importance of the Research Achievements

本研究は、眼瞼黄色腫の発生機構の一端を明らかにし、この疾患の予防につながる可能性を示した。また、この機構に接着分子ICAM1が重要な役割を示すことより、この接着分子の阻害が眼瞼黄色腫治療に役立つ可能性も示したと考えられる。