2023 Fiscal Year Final Research Report
Examination of gastrointestinal differentiation and expression status of cancer stromal markers in extrahepatic cholangiocarcinoma
| Project/Area Number |
21K06927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 肝外胆管癌 / 胃腸分化形質 / 癌間質 |
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| Outline of Final Research Achievements |
To clarify the relationship between the direction of gastrointestinal differentiation and cancer stroma in hilar and distal cholangiocarcinoma, we examined the expression of cancer-associated fibroblasts (CAFs), tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and gastrointestinal differentiation markers. We reviewed all collected and HE specimens of surgically treated cholangiocarcinoma cases and evaluated pathological findings such as primary location, histological type, depth, vascular invasion, carcinoma in situ, budding, and marker expression. The results showed that the degree of perineural invasion (distal>hilar), vascular invasion (distal>hilar), MUC5AC expression, and TIL and TAM expression may differ by site. No relationship was found between the direction of epithelial gastrointestinal differentiation and CAFs, TILs, or TAMs.
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| Free Research Field |
人体病理
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| Academic Significance and Societal Importance of the Research Achievements |
胆管癌はアジアに罹患者が多く，我が国においても癌による臓器別死亡原因では第6位で，5年生存率は20%前後と膵癌に次いで悪性度が高い．本研究では肝門部胆管癌と遠位胆管癌の胃腸分化方向と癌間質との関連性を明らかにするため病理所見，癌関連線維芽細胞(CAFs), 腫瘍浸潤リンパ球(TILs), 腫瘍関連マクロファージ(TAMs), 胃腸分化マーカーの発現を検討したところ，神経浸潤の程度，脈管侵襲の程度(遠位>肝門部)，MUC5ACの発現，TILsとTAMsの発現状況が部位により異なる可能性が示された．胆管癌の腫瘍発生・進展のメカニズムを解明することは，胆管癌の治療につながる重要な課題である．
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