2023 Fiscal Year Final Research Report
Role of host polyamines in Salmonella pathogenesis
| Project/Area Number |
21K07011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49050:Bacteriology-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | ポリアミン / サルモネラ / マウス感染モデル / 病原因子 |
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| Outline of Final Research Achievements |
Polyamines are aliphatic polycations that are ubiquitous in almost all living organisms, including animals and microbes. Earlier studies have demonstrated that, in addition to pivotal physiological functions, polyamines are also involved in multiple aspects of bacterial pathogenesis. Salmonella enterica serovar Typhimurium is an entero- and intracellular-pathogenic bacterium causing life-threatening infections ranging from gastroenteritis to systemic infection. Polyamines have been reported to contribute to S. Typhimurium pathogenesis, however, the role of polyamines is not fully understood. In this study, we clarify that S. Typhimurium utilizes the polyamines of its hosts in order to infect them. Polyamine homeostasis in S. Typhimirum is required for functional expression of virulence factors. These results also suggest that controlling the host polyamine levels could be a promising avenue for treatment of Salmonella infection.
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| Free Research Field |
細菌学
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| Academic Significance and Societal Importance of the Research Achievements |
病原細菌サルモネラの病原性発現に関わるポリアミン恒常性は宿主からの取り込みに依存しており、エフロルニチン（ジフルオロメチルオルニチン）による宿主ポリアミンの阻害はサルモネラの感染性を抑制した。エフロルニチンはアフリカ睡眠病の治療薬として用いられている承認された薬剤であることから、本研究結果はその適応をサルモネラ感染に拡大する可能性を示唆した。さらに、ポリアミンよる病原因子の制御機構が明らかにすることは、ポリアミンおよびそれに関連した分子をターゲットとした新たな抗菌薬（抗感染症薬）の開発における分子基盤になると期待される。
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