Physiological and ecological roles of type VI secretion system in Helicobacter cinaedi.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07026
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49050:Bacteriology-related
• Research Institution: Kyushu University
• Principal Investigator: Gotoh Yasuhiro 九州大学, 医学研究院, 助教 (20558358)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Helicobacter cinaedi / VI型分泌系 / エフェクター / 常在性 / 病原性

Outline of Final Research Achievements

For searching effectors of the type VI secretion system of Helicobacter cinaedi, the 48 candidate genes with lethal effects on Escherichia coli were expressed alone. The gene encoding the microbial ribonuclease-like domain repressed E. coli growth. Although the gene repressed the growth of E. coli, the strain did not inhibit the growth of other lineages or the closely related species of H. cinaedi strains, and H. fennelliae, the second most frequently isolated species next to H. cinaedi from the human intestinal tract.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

これまでHelicobacter cinaediのVI型分泌系の生理生態学的な役割は不明であったが、本研究で大腸菌に致死的な作用を示す遺伝子を見つけたことにより本菌のT6SSが少なくとも細菌-細菌間競争に関わることが明らかになった。本菌種のような存在量の乏しい菌種が、生存競争の激しいヒト腸内で常在性を維持する機構の解明は、ヒト腸内エコシステムの理解に貢献するだけでなく、本菌の制御法の開発にもつながると期待できる。