Relationship between gastric nitrate-reducing bacteria and disease associated with Helicobacter pylori infection

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07366
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Okayama University
• Principal Investigator: YOKOTA KENJI 岡山大学, 保健学域, 教授 (00243460)
• Co-Investigator(Kenkyū-buntansha): 岡田 裕之 岡山大学, 医歯薬学総合研究科, 特命教授 (60263563) ; 渡辺 朱理 徳島大学, 大学院医歯薬学研究部(歯学域), 講師 (80585026)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: Helicobacter pylori / 硝酸塩還元菌 / 細胞性免疫 / 液性免疫 / Klebsiella / Rothia

Outline of Final Research Achievements

Helicobacter pylori is an important risk factor for the development of gastric cancer, and in recent years, it has been suggested that nitrate-reducing bacteria that grow in the stomach in association with Helicobacter pylori infection may also be involved in the development of gastric cancer. The main nitrate-reducing bacteria isolated from patients can be divided into two types: oral bacteria and intestinal bacteria, and past research has revealed that the proportion of intestinal bacteria becomes more prevalent as the gastric condition worsens.

Free Research Field

感染免疫学

Academic Significance and Societal Importance of the Research Achievements

ピロリ菌は胃癌発症の重要なリスク因子であるが、近年、ピロリ菌感染に付随して胃内で増殖する硝酸塩還元菌も胃癌発症に関与しているのではないかと考えられている。患者から分離される主な硝酸塩還元菌は口腔細菌と腸内細菌の2種類に分類できるが、過去の研究で胃の病態が悪化するほど腸内細菌の割合が優位になっていることが判明した。