2023 Fiscal Year Final Research Report
Metabolomics of biomolecules in serum from individuals with at-risk mental state and first-episode psychosis: discovery of reliable marker to develop psychosis
| Project/Area Number |
21K07399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
辻野 尚久 東邦大学, 医学部, 客員准教授 (00459778)
田形 弘実 東邦大学, 医学部, 助教 (50888542)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | At-risk mental state / LC-MS/MS / 乳酸 / 有機酸 / プレカラム誘導体化試薬 |
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| Outline of Final Research Achievements |
Early intervention to subjects with at-risk mental state (ARMS) is effective for preventing the etiology of serious psychiatric diseases, however, there have been a few reports on biochemical or clinically chemical studies such as changes of biomolecules levels in ARMS subjects.
In the present study, several organic acids having one or two carboxyl groups in human serum were derivatized with a newly designed and synthesized pre-column reagent, CIM-C2-NH2, and subsequent quantitative analysis by LC-MS/MS. As a consequence, serum L-lactate levels in ARMS subjects were significantly decreased than those in healthy subjects, suggesting that some disorder of glycolytic pathway may occur in ARMS.
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| Free Research Field |
分析化学
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| Academic Significance and Societal Importance of the Research Achievements |
精神科医療の現場では、患者の血圧測定や血液中グルコース濃度のように、数値で示される客観的な疾患診断マーカーとなりうるものがない。本研究では精神病を発症するかもしれない発症危険状態（ARMS）に着目した。
ARMSの血清を、当研究室で開発したオリジナル分析法で調べた結果、ARMS血清ではL-乳酸とグルコースの比（L-乳酸/グルコース）が健常人の方よりも著しく低かったので、ARMSは、精神病の発症前であるが、すでに解糖系に異常がある可能性が見いだされた。本研究で得られた結果を基にして、精神病の発症予防や早期治療に繋がる研究が今後、展開され、精神科医療に役立っていくと期待される。
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