2023 Fiscal Year Final Research Report

Development of assessment method for lymphatic system in the brain: Evaluation of the influence by sleep.

Research Project

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Project/Area Number	21K07563
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Nagoya University
Principal Investigator	Taoka Toshiaki 名古屋大学, 医学系研究科, 特任教授 (30305734)
Co-Investigator(Kenkyū-buntansha)	宮田聖子名古屋大学, 医学系研究科, 特任講師 (40560917) 川井恒愛知医科大学, 医学部, 准教授 (50378147) 岩本邦弘名古屋大学, 医学系研究科, 准教授 (50569796) 野田明子中部大学, 臨床検査技術教育・実習センター, 教授 (80252287) 伊藤倫太郎名古屋大学, 医学系研究科, 特任助教 (80813336)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	Glymphatic system / MRI / Diffusion / DTI-ALPS
Outline of Final Research Achievements	An imaging assessment of cerebral interstitial fluid dynamics related to sleep revealed significant correlations with the ALPS-index. The analysis showed an inverse correlation between the index and latency to persistent sleep, and positive correlations with total sleep time and sleep efficiency. Multiple regression analysis demonstrated that poor sleep parameters, excluding latency to sleep onset, led to a decrease in the ALPS-index. A linear mixed model suggested that initial sleep conditions might influence the ALPS-index later. Additionally, Ktrans measurements showed a significant correlation with latency to sleep onset, and choroid plexus volume negatively correlated with total sleep time, indicating that worse sleep conditions are associated with major changes in the ALPS-index. These findings emphasize the impact of sleep quality on brain fluid dynamics and the importance of managing sleep disorders.
Free Research Field	神経放射線学
Academic Significance and Societal Importance of the Research Achievements	Glymphaticシステムは、脳内の老廃物を排出する重要な機序であり、血管周囲腔を中心に脳脊髄液や脳間質液が流れることで機能する。このシステムは特に睡眠中に排泄効率が向上する。本研究ではその非侵襲的な評価の方法として、拡散画像を用いたdiffusion tensor image analysis along the perivascular space（DTI-ALPS）などでの評価を行った。これらの手法を活用することにより、睡眠とGlymphaticシステムの関係を明らかにし、睡眠の質の低下が認知機能に与える影響の評価や予防、改善策の開発が期待されている。