2023 Fiscal Year Final Research Report
Development of advanced MRI for brain tumor assessment visualizing cell morphology
| Project/Area Number |
21K07569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
上村 清央 鹿児島大学, 医歯学域医学系, 准教授 (30593652)
中條 正典 鹿児島大学, 医歯学域医学系, 客員研究員 (60727171)
熊澤 誠志 北海道科学大学, 保健医療学部, 教授 (50363354)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | MRI / 脳腫瘍 / 拡散強調画像 / 細胞形態 / 拡散異方性 |
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| Outline of Final Research Achievements |
This study aimed to establish a non-invasive method for evaluating the cell morphology in brain tumors. We introduced and optimized double diffusion encoding (DDE) MRI to a clinical MRI scanner, and developed computer applications for calculating maps of microscopic FA (microFA), which is a quantitative metric for diffusion anisotropy within a microscopic domain. microFA was significantly higher in meningioma, which consists of cells with elongated shape than glioblastoma, which has round or irregular-shaped cells, suggesting that microFA derived from DDE MRI can reflect the morphology of tumor cells. microFA was shown useful for differentiating brain metastasis from glioblastoma, but appeared to be less useful for differentiating malignant lymphoma from glioblastoma. This study suggested that DDE MRI may provide valuable information regarding tumor cell morphology, but warranted further technical improvements.
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| Free Research Field |
放射線医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、腫瘍細胞の形態という、これまで注目されなかった腫瘍の特徴に着目し、先進的な拡散強調MRIの技術を用いて非侵襲的に評価することで、新たなバイオマーカ―として利用できる可能性を示した、非常に新規性の高い研究である。脳腫瘍は、依然として難治な疾患であり、診断・治療技術の進歩が望まれている。本研究では、脳腫瘍の鑑別診断における有用性を示したが、今後さらに研究を進め、治療効果や予後予測などへの応用が確立できれば、さらに大きな社会的な意義を持つ。
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