2023 Fiscal Year Final Research Report
Characterization of a New X-ray Contrast Agent with Hepatocellular Contrast Potential
| Project/Area Number |
21K07574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 由美子 上智大学, 理工学部, 教授 (20295546)
南部 伸孝 上智大学, 理工学部, 教授 (00249955)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 造影剤 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the properties of new X-ray contrast agents with hepatocellular contrast capability. We focused on the asialoglycoprotein receptor (ASGPR) and prepared three candidate compounds (RYO-1, MEG-1, and MEG-2) with a side chain that binds to the ASGPR. These compounds bound to ASGPR in vitro and were excreted from the liver and kidney in vivo. In addition, lead compounds with three identical side chains (RYO-1 → RYO-2, MEG-2 → MEG-4) were synthesized and compared in terms of affinity for ASGPR. RYO-2 showed higher receptor affinity than MEG-4.
Although the data are preliminary at this time, it is assumed that the ratio of RYO-2 excretion from the liver and kidney in healthy mice is approximately 3:2. Based on the above, RYO-2 is now considered a candidate for a new contrast agent, and further studies will be continued.
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| Free Research Field |
消化器内科学
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| Academic Significance and Societal Importance of the Research Achievements |
ヨード性造影剤による造影X線検査は診断の正確性を高め、重要な検査の一つとなっている。しかし、ヨード性造影剤は腎臓より排泄され、腎機能高度障害例で は使用できない。腎機能低下症例は加齢と共に増加することが知られており、我が国の人口高齢化を考えると、腎障害を軽減した新規X線造影剤の開発は喫緊の 課題と言える。
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