Construction of higher-order dysfunction diagnosis system after anterior communicating artery aneurysm by non-contrast perfusion MRI

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tohoku University
• Principal Investigator: Yamazaki Tetsuro 東北大学, 大学病院, 助教 (70250769)
• Co-Investigator(Kenkyū-buntansha): 麦倉 俊司 東北大学, 東北メディカル・メガバンク機構, 教授 (20375017) ; 高橋 昭喜 東北大学, 医学系研究科, 非常勤講師 (80148874) ; 森 菜緒子 東北大学, 医学系研究科, 助教 (90535064)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 前交通動脈瘤 / 高次脳機能障害 / 記憶 / 健忘症 / 前脳基底部

Outline of Final Research Achievements

After surgery for anterior communicating artery aneurysms, cognitive impairments, primarily memory disorders, often occur. We have reported that damage to the subcallosal artery, a branch of the anterior communicating artery, and damage to the basal forebrain area it supplies, are associated with memory impairments, using 3D-MRI. This study reports that reduced blood flow in the basal forebrain area, as shown by brain blood flow SPECT, is associated with memory disorders. This report is the first to indicate that the memory impairments frequently occurring after surgery for anterior communicating artery aneurysms are caused by damage to the subcallosal artery and reduced blood flow in its perfusion area. Additionally, the clinical utility of the ASL method, a non-invasive alternative to SPECT for measuring brain blood flow, was tested and evaluated.

Free Research Field

神経学

Academic Significance and Societal Importance of the Research Achievements

前交通動脈瘤術後にはしばしば記憶障害を主とする高次機能障害が生じる．我々は3D-MRIを用いて前交通動脈穿通枝のsubcallosal artery の損傷とその灌流領域を含む前脳基底部の損傷が記憶障害に関連することを報告した．本研究では，脳血流SPECTにより，前脳基底部の血流低下が記憶障害に関連することを報告した．本報告は，前交通動脈瘤術後にしばしば生じる記憶障害が，subcallosal artery の損傷とその灌流領域の血流低下が原因であることを初めて報告したものである．