Investigation of the relationship between the therapeutic efficacy of boron neutron capture therapy and the residence of boron drugs in tumors.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka Metropolitan University (2022-2023); Osaka Prefecture University (2021)
• Principal Investigator: Wada Yusuke 大阪公立大学, 大学院獣医学研究科, 特任講師 (10866172)
• Co-Investigator(Kenkyū-buntansha): 鈴木 実 京都大学, 複合原子力科学研究所, 教授 (00319724)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ホウ素中性子捕捉療法 / BPA / 間質

Outline of Final Research Achievements

Two pancreatic cancer cell lines, PSN1 and Capan-1, which differ in the amount of stroma, were used to create tumor-bearing mouse models. One hour after intraperitoneal administration of BPA to each mouse, tissue was harvested and the boron concentration in the tissue was measured. In addition, the tumors of each mouse were irradiated with neutrons one hour after BPA administration, and the tumor growth inhibitory effect was observed.
Finally, alpha autoradiography using CR39 was performed to observe the distribution of BPA in tumor tissue at the time of irradiation. No significant difference in distribution to stroma and cells was observed between the two.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

現在BNCTの治療効果予測は[18F]FBPAを用いたPET検査によって行われている。しかし、BPAのマクロな取込み量だけではBNCT効果予測が不十分であることが今回の研究データから示唆された。本研究は、BPAの取込み量だけではなく組織中の間質の割合も考慮した治療効果予測の開発に向けた基礎的データとなると考えらえる。