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2023 Fiscal Year Final Research Report

MR sequence improvement and its siganal anlytic model based on apin labeling for new brain functional images

Research Project

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Project/Area Number 21K07616
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionUniversity of Fukui

Principal Investigator

Kimura Hirohiko  福井大学, 学術研究院医学系部門, 名誉教授 (10242596)

Co-Investigator(Kenkyū-buntansha) 石田 翔太  京都医療科学大学, 医療科学部, 助教 (50817559)
藤原 康博  熊本大学, 大学院生命科学研究部(保), 教授 (90422675)
松田 祐貴  福井大学, 学術研究院医学系部門(附属病院部), 放射線技師 (40896841)
竹内 香代  福井大学, 学術研究院医学系部門, 助教 (90750836)
Project Period (FY) 2021-04-01 – 2024-03-31
KeywordsArterial spin labeling / MRI / Brain perfusion / CBF / CBV / Transit time
Outline of Final Research Achievements

By combining the DANTE method and ASL blood flow imaging, we were able to propose an MR imaging method and signal analysis model to calculate ASL-CBF and arterial side blood volume (aCBV) (S. Ishida, H. Kimura, N. Takei, Y. et al. MRM). Using this model, we reported that ASL-TTT and CBF can be used to evaluate cerebral circulation and metabolism in patients with moyamoya disease and chronic occlusive cerebral artery disease, since the ASL-TTT significantly correlates with both local OEF and cerebral reactivity from PET study(Takata, et.al. Diagnostics 2023; K. Takeuchi, et.al. Magn Reson Med Sci 2022).

Free Research Field

放射線医学分野

Academic Significance and Societal Importance of the Research Achievements

脳循環代謝、血管反応性を計るには、これまでPETやSPECT検査で、放射性薬剤の投与や血管拡張薬剤を使用する必要があった。MRI撮像法の一つである、スピンラベル(ASL)法は、特に中枢神経系の機能画像診断で利用されつつある。今回の結果より、ASL-TTT, CBFのパラメタを利用することで、完全に非侵襲的に脳循環代謝の評価が可能となれば、その社会的意義は大きい。

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Published: 2025-01-30  

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