The role of innate immune responce and the mechanism of fibrosis in type 1 autoimmune pancreatitis.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07943
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kochi University
• Principal Investigator: UCHIDA KAZUSHIGE 高知大学, 教育研究部医療学系臨床医学部門, 教授 (40411516)
• Co-Investigator(Kenkyū-buntansha): 池浦 司 関西医科大学, 医学部, 准教授 (50454608)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: １型自己免疫性膵炎 / MAIT細胞 / iNKT細胞 / γδT細胞

Outline of Final Research Achievements

We previously reported the role of M2 macrophage and basophil in type 1 autoimmune pancreatitis. Moreover, neutrophil which is characteristic in type 2 AIP, play an important roll in type 1 AIP. Recently, invariant T cells such as Mucosal-associated invariant T cell（MAIT cell）、invariant natural killer T cell(iNKT cell)、γδT cell is receiving a lot of attention in pathophysiology in several diseases.
Then we examined peripheral MAIT cell, iNKT cell and γδT cell in the patients wit type 1 AIP.
There is no significant difference among healthy control group, chronic pancreatitis group and type 1 AIP groups.

Free Research Field

膵臓病学

Academic Significance and Societal Importance of the Research Achievements

近年、自然免疫反応が様々な疾患に関与されていることが報告されており、本研究はその中でも近年注目されているMAIT細胞、iNKT細胞、γδT細胞について検討したことは、１型AIPの病態解明には重要な役割を果たしたと考える。