The construction of new risk model for esophageal squamous cell carcinoma

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K07963
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Hiroshima University
• Principal Investigator: URABE YUJI 広島大学, 病院(医), 寄附講座准教授 (10648033)
• Co-Investigator(Kenkyū-buntansha): 田中 信治 広島大学, 病院(医), 名誉教授 (00260670) ; 岡 志郎 広島大学, 医系科学研究科(医), 教授 (30403538)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 食道扁平上皮癌 / 非飲酒非喫煙者 / 高齢女性 / CDKN2A / KMT2D

Outline of Final Research Achievements

The study aimed to examine the clinicopathological and genomic characterizations of ESCCs developed from female who do not have habits of drinking and smoking. Older non-drinker non-smoker females with RE and less multiple LVLs were more likely to develop longitudinal protruded/flat ESCC with keratinization of the posterior wall of the mid-thoracic esophagus, and were genetically characterized by more CDKN2A mutations and fewer KMT2D mutations.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

逆流性食道炎を持つ高齢の非飲酒・非喫煙女性では，まだら食道がなくても、胸部中部食道後壁にCDKN2A変異が多く，KMT2D変異が少ない角化を伴う縦長の食道扁平上皮癌が発生することがあり注意を要する。