Innovation of the tachycardia entity, diagnosis and therapy of atrioventricular ring tachycardia

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08022
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Gunma University
• Principal Investigator: Kaneko Yoshiaki 群馬大学, 医学部, 客員教授 (60302478)
• Co-Investigator(Kenkyū-buntansha): 中島 忠 群馬大学, 医学部, 客員准教授 (40510574)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 房室弁輪頻拍

Outline of Final Research Achievements

We have identified some variants extending outside Koch’s triangle along the tricuspid annulus and summarized the similarities between the superior-type of fast-slow atrioventricular (AV) nodal reentrant tachycardia (NRT) using superior slow pathway (SP) and adenosine-sensitive atrial tachycardia originating near the AV node, and between fast-slow AVNRT using a superoanterior or inferolateral right atrial SP and atrial tachycardia originating from the tricuspid annulus, including anatomical distributions and electrophysiological and pharmacological characteristics of the tachycardia origin. Moreover, based on recent basic research reporting the presence of node-like AV ring tissue encircling the annuli in adult hearts, we propose the term “AV ring tachycardia” to designate the tachycardias that share the AV ring tissue as a common arrhythmogenic substrate. We hope, with this proposal of a unified tachycardia designation, to open a new chapter in clinical electrophysiology.

Free Research Field

臨床心臓電気生理学

Academic Significance and Societal Importance of the Research Achievements

学術的には、まず不整脈原性組織としての房室弁輪組織の電気生理学的・薬理学的・解剖学的理解の向上が期待できる。また、房室弁輪を基質とする頻拍の発生メカニズムの解明につながることや、実地臨床に関して房室弁輪組織を標的とした新しいアブレーション治療の開発につながることが期待される。