The role of coagulation and complement systems in the pathogenesis of CSU

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Hiroshima University
• Principal Investigator: Yanase Yuhki 広島大学, 医系科学研究科(薬), 准教授 (40452586)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 慢性蕁麻疹 / 血液凝固 / 補体 / マイクロパーティクル

Outline of Final Research Achievements

Chronic spontaneous urticaria (CSU) is characterized by daily or almost daily recurring wheal and flare with itch for more than 6 weeks. The extrinsic coagulation system has been shown to be activated in correlation with CSU severity. However, detailed relationship between the pathogenesis of CSU and coagulation system has not been clear. We here clarified that tissue factor (TF), a trigger of the extrinsic coagulation cascade, expressed on vascular endothelial cells plays critical roles in CSU and activated complement, C5a, are also important for basophils and mast cells activation in CSU. Moreover, we demonstrated that micro particles (MP) released from vascular endothelial cells have important roles in the pathogenesis of CSU.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

本研究では、慢性蕁麻疹の病態と、血液凝固反応・補体系の関係の一部を解明し、また、血液内物質が慢性蕁麻疹の診断に応用できる可能性を示した。本成果は、難治性慢性蕁麻疹の新しい治療薬の開発と診断法の開発につながるものと期待する。