Identification of novel molecular mechanisms regulating insulin secretion from pancreatic beta cells and their physiological significance

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08551
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Shinshu University
• Principal Investigator: Komatsu Mitsuhisa 信州大学, 学術研究院医学系, 教授 (90221978)
• Co-Investigator(Kenkyū-buntansha): 大久保 洋輔 信州大学, 学術研究院医学系(医学部附属病院), 助教 (70793925)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: インスリン分泌 / ブドウ糖

Outline of Final Research Achievements

The metabolic amplification pathway is a physiologically important mechanism of insulin secretion by glucose. The mechanism involves glucose metabolism and lipid messengers. We have found that the 25kD islet protein is one of the molecular bases for this pathway. As a result of this research project, the islet protein was identified as PGRMC1 (progesterone receptor membrane associated component 1). We also demonstrated that one location of PGRMC1 extracted from rat islets is palmitoylated in vitro.

Free Research Field

内分泌代謝学

Academic Significance and Societal Importance of the Research Achievements

本研究は３０年間にわたり我々が研究してきた代謝性増幅経路の分子基盤を確立し、その生理的役割を証明する集大成の位置を占める。ブドウ糖による代謝性増幅経路を担う新規分子でとしてPGRMC1を同定できたことは、インスリン分泌機構における代謝性増幅経路の分子基盤に新たな道筋をつける、極めて学術的独自性に富む研究成果である。代謝性増幅経路の分子基盤の解明はインスリン分泌機構の解明とともにこの分野のさらなる研究の発展につながることになるだろう。