Establishment of a novel treatment for pediatric liver tumor using liposomal formulated indocyanine green derivative

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08660
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Chiba University
• Principal Investigator: Komatsu Shugo 千葉大学, 医学部附属病院, 講師 (60436417)
• Co-Investigator(Kenkyū-buntansha): 菱木 知郎 千葉大学, 大学院医学研究院, 教授 (00375776) ; 菅波 晃子 千葉大学, 大学院医学研究院, 助教 (10527922) ; 田村 裕 千葉大学, 大学院医学研究院, 准教授 (50263174) ; 照井 慶太 千葉大学, 大学院医学研究院, 准教授 (70375773) ; 中田 光政 千葉県がんセンター(研究所), その他部局等, 主任医長 (90375775)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 光線力学的治療 / インドシアニングリーン / リポソーム

Outline of Final Research Achievements

A significant decrease in the number of viable cells was observed in the MTT assay in cells that had been irradiated with ICG-Lipo and subjected to PDT using near-infrared light. In addition, ICG-Lipo injected into a mouse subcutaneous tumor model and irradiated with near-infrared light showed a marked inhibition of tumor growth. Furthermore, when low-dose CDDP was included in ICG-Lipo, the tumor growth inhibitory effect was even stronger than that in the ICG-Lipo group. However, the tumor growth inhibitory effect in the group simply treated with a mixture of ICG-Lipo and low-dose CDDP was not significantly different from that in the group treated with ICG-Lipo alone. These results suggest that the inclusion of CDDP in ICG-Lipo can effectively inhibit tumor growth even at low doses.

Free Research Field

小児がん

Academic Significance and Societal Importance of the Research Achievements

本研究により肝腫瘍におけるICG-Lipoを用いた光線力学的治療の有効性が確認された。さらにICG-Lipoに抗腫瘍薬であるシスプラチンを内包することで、低用量の抗腫瘍薬による最大効果・最小副作用の実現が達成され、光免疫治療の分野に新たな道を拓くことが期待された。