Development of a new minimally invasive treatment for bile duct disease using a bioabsorbable bile duct substitute

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: International University of Health and Welfare (2023); Teikyo University (2021-2022)
• Principal Investigator: Miyazawa Mitsuo 国際医療福祉大学, 国際医療福祉大学成田病院, 教授 (20200165)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 胆管再生 / 胆管代替物 / 生体吸収性材料 / 胆管損傷

Outline of Final Research Achievements

In this study, we aimed to develop a bioabsorbable bile duct substitute (BBDS) that can directly repair bile duct defects and regenerate bile ducts at the site. Specifically, we will use BBDS to regenerate the bile duct in a Y-shape (mimicking the left and right hepatic ducts) with the aim of making surgery for cholangiocarcinoma in the hepatic hilus area less invasive, and we will also endoscopically repair bile duct defects. We investigated whether it is possible to treat bile duct damage during laparoscopic cholecystectomy, and developed a new minimally invasive treatment method for biliary diseases. During the three years of this study, using this BBDS, it became possible to regenerate Y-shaped bile ducts without stricture up to an early stage (about 1 month). The BBDS used in this study is optimal as a scaffold for regenerating bile ducts, and is thought to be usable in the near future.

Free Research Field

消化器外科

Academic Significance and Societal Importance of the Research Achievements

現在、外科治療の方向性は機能温存および低侵襲にあるが、肝外胆管欠損の治療法は、乳頭部機能を廃絶した胆管―腸再建が通常行われ、機能温存の方向にはない。この研究により、本研究で用いたような生体吸収性胆管代替物を用いることにより、胆管疾患部を切除後、その欠損部を復元する手術の可能性がしめされた。このような手術により、近未来には、肝胆膵手術の低侵襲化および機能温存を図ることが可能となる。