Control of implantable ventricular assist device driveline exit site infection by infrared irradiation

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Tohoku University
• Principal Investigator: Ktahira Shintaro 東北大学, 大学病院, 講師 (80870138)
• Co-Investigator(Kenkyū-buntansha): 窪田 博 杏林大学, 医学部, 教授 (00262006) ; 坂爪 公 東北大学, 医学系研究科, 大学院非常勤講師 (10837032) ; 齋木 佳克 東北大学, 医学系研究科, 教授 (50372298) ; 青柳 哲史 東邦大学, 医学部, 准教授 (50581609)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 補助人工心臓 / 重症心不全 / ドライブライン感染 / 近赤外線

Outline of Final Research Achievements

Infrared irradiation of experimental small animal wound models was performed using a prototype infrared irradiator from Kyorin University, and adverse events such as delayed wound healing and carbonisation of skin tissue were observed at irradiation conditions above a certain level, suggesting that irradiation at 10-20% power and 10-20 s continuous irradiation time could be performed without adverse events. Irradiation conditions of 10-20% power and 10-20 s continuous irradiation time were considered sufficient for irradiation without adverse events. No degeneration was observed under the irradiation conditions of 10-20% power and 10-20 s irradiation time.
When the device was used to irradiate skin tissue infected with Staphylococcus aureus, a decrease in the amount of bacteria was observed.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

実験小動物を用いた赤外線照射実験により、有害事象が起こらない照射条件でも照射された皮膚組織の表皮黄色ブドウ球菌菌量が減少することが確認された。
植込型補助人工心臓装着患者におけるもっとも頻度が多い合併症であるドライブライン感染は治療抵抗性があり根治的な治療法がないことが問題となっていたが、本研究の結果から赤外線照射により有害事象なく治療しうる可能性が示唆された。