Abdominal aortic aneurysms and the coagulation-and fibrinolytic system

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08858
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Tanaka Hiroki 浜松医科大学, 医学部, 特任研究員 (50456563)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 腹部大動脈瘤 / 血栓 / 線溶療法

Outline of Final Research Achievements

The progression (enlargement and rupture) of abdominal aortic aneurysms (AAA) has been clinically shown to correlate with the size of intramural thrombus; however, the detailed pathogenesis and formation mechanisms remain unclear. This study suggests that the presence of residual intramural thrombus in the progression of AAA may also influence the coagulation-fibrinolysis system. Discussion on the similarity of AAA model animals has been ongoing, highlighting the need to identify and verify differences. However, since therapeutic agents that affect the coagulation-fibrinolysis system have already been reported to be effective in other diseases, extracting therapeutic agents targeting intramural thrombus in AAA by exploring existing reports is considered an intriguing approach.

Free Research Field

大動脈瘤

Academic Significance and Societal Importance of the Research Achievements

腹部大動脈瘤（AAA）は、侵襲的な外科手術しか治療方法のなかったが、本研究の成果から、既知の治療報告を探索することによって、AAAの壁在血栓をターゲットにした治療薬の発掘に寄与すると考えられる。