Analysis of blood flow in the sinus of Valsalva for predicting the development of prosthetic valve thrombosis after TAVI

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08870
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Kyushu University
• Principal Investigator: Sonoda Hiromichi 九州大学, 大学病院, 講師 (50596830)
• Co-Investigator(Kenkyū-buntansha): 米倉 隆介 九州大学, 大学病院, 医員 (20725725) ; 松田 健作 九州大学, 大学病院, 医員 (40792924)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: TAVI

Outline of Final Research Achievements

Since 3DCT cannot evaluate blood flow in real time, we attempted to evaluate the difference between HALT and non-HALT groups by performing neo-sinus blood flow analysis with 4D flow MRI.We introduced a 4D flow MRI sequence to our 1.5T MRI and attempted to analyze neo-sinus, but it was difficult to perform accurate blood flow analysis because of signal reduction due to artificial valve artifacts.We then switched to blood flow analysis at the STJ and ascending aorta levels, and compared blood flow analysis between HALT and non-HALT cases. However, we could not find any significant differences in the results of blood flow analysis, including wall shear stress and energy loss.

Free Research Field

TAVI

Academic Significance and Societal Importance of the Research Achievements

TAVI術後の人工弁血栓症のハイリスク症例を抽出して術後抗凝固療法の効果を再検証することにより抗凝固療法の有益性を見直す点が、これまでの研究とは異なる新しい研究である。本研究の結果は、血流うっ滞を少なくするための手術手技開発やデバイスの改良につながると考えている。