Hydrogen gas inhalation for suppression of lung oxygenation impairment in acute aortic dissection

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08875
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: Kawata Mitsuhiro 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60431863)
• Co-Investigator(Kenkyū-buntansha): 大澤 郁朗 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (30343586)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 急性大動脈解離Stanford B型 / 水素吸入療法 / 急性肺障害 / 心臓血管外科 / 肺酸素化障害

Outline of Final Research Achievements

The safety of hydrogen gas inhalation therapy was confirmed as the first step in an exploratory study to determine whether hydrogen gas inhalation therapy can be established as a new treatment modality to prevent or reduce pulmonary oxygenation disorders associated with acute aortic dissection Stanford type B. All 10 patients who consented to participate in the study had stable respiratory status without the need for ventilators or NIPPV, and were discharged home after a stable inpatient stay in the acute phase. The length of hospital stay and the highest CRP value were not significantly different from those in the historical control data (2020-2021). The safety of the treatment was confirmed.

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

水素ガス吸入療法によるサイトカインストーム抑制を急性大動脈解離の治療に用いる臨床研究はこれが世界で初めてである。そのために必要な水素ガス投与法の確立は他疾患での水素ガス吸入療法にとっても重要な知見を提供することになり、極めて高い独自性と創造性を備えている。