The development of surgical adhesive material with high pressure resistance and conformability

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K08879
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: University of Tsukuba
• Principal Investigator: Sato Yukio 筑波大学, 医学医療系, 教授 (10312844)
• Co-Investigator(Kenkyū-buntansha): 小林 尚寛 筑波大学, 医学医療系, 講師 (10746564) ; 田口 哲志 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (70354264)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 外科用接着剤 / 肺瘻 / 気漏 / ゼラチン

Outline of Final Research Achievements

The adhesive quality of novel surgical sealant (Gelatin sealant: GS) was evaluated compared with conventional surgical sealant (Fibrin glue: FG). GS showed high adhesive quality and conformability in excised porcine lungs. GS showed high adhesive quality in anesthetized pig lungs. In chronic rat experiment, GS and FG caused no adverse events. While FG was absorbed in 2 weeks with some inflammatory response, GS was absorbed in 8 weeks with less inflammatory response.

Free Research Field

呼吸器外科学

Academic Significance and Societal Importance of the Research Achievements

新規組織接着剤 (Gelatin sealant: GS)はex vivo、in vivo実験にて高い接着力・追従性を示し、慢性実験でも有害事象を認めず惹起する炎症反応も軽度であった。呼吸器外科手術に於ける最も頻度の高い合併症である気漏閉鎖への臨床応用が期待できる。