Analysis of neuroprotective effect of DBS on Parkinson's disease using mitochondrial imaging

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Nozaki Takao 浜松医科大学, 医学部附属病院, 講師 (10598494)
• Co-Investigator(Kenkyū-buntansha): 浅川 哲也 浜松医科大学, 医学部, 特任研究員 (00469917) ; 黒住 和彦 浜松医科大学, 医学部, 教授 (20509608) ; 尾内 康臣 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: パーキンソン病 / 視床下核脳深部刺激術 / ドパミントランスポーター / ミトコンドリア

Outline of Final Research Achievements

Patients with Parkinson’s disease who had undergone bilateral STN-DBS were scanned twice with [11C]CFT PET before and after surgery. Correlation analysis was conducted between [11C]CFT binding and “OFF” period Unified Parkinson’s Disease Rating Scale (UPDRS) scores assessed preoperatively and postoperatively.
[11C]CFT uptake increased in the contralateral anteroventral putamen and ipsilateral ventral caudate postoperatively. The %reduction in UPDRSIII was significantly correlated with the %increase in [11C]CFT binding in the ipsilateral anteroventral putamen　and ventral caudate. STN-DBS increases dopamine transporter levels in the anteroventral striatum, which is correlated with the motor recovery and possibly suggests the neuromodulatory effect of STN-DBS on dopaminergic terminals in Parkinson’s disease patients. A preoperative level of anterior striatal dopamine transporter may predict reserve capacity of STN-DBS on motor recovery.

Free Research Field

機能的脳神経外科

Academic Significance and Societal Importance of the Research Achievements

今回パーキンソン病に対する視床下核脳深部刺激術後に認められた線条体前腹側部のドパミントランスポーター上昇は、パーキンソン病の自然経過とは異なる所見であり、同手術の作用機序、神経保護作用、ニューロモデュレーション効果の一端を示している可能性がある。パーキンソン病の各症例における手術の効果予測・より良い手術時期の決定、より効果の高い刺激調整・薬剤調整等の解明につながるものと期待される。