Inhibition of Synovitis by Anti-Podoplanin Antibody in a Rabbit Arthritis Model

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09219
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Yamagata University
• Principal Investigator: Honma Ryusuke 山形大学, 医学部, 非常勤講師 (70716688)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: ポドプラニン

Outline of Final Research Achievements

Podoplanin is a type I transmembrane protein and is expressed in normal tissues such as renal glomerular epithelial cells, lung type I alveolar epithelial cells, osteocytes, and chondrocytes, as well as in pathological tissues such as malignant tumors and synovial tissue of rheumatoid arthritis. We induced synovitis by injecting lipopolysaccharide into the knee joints of rabbits and found that podoplanin is expressed in synovial tissues. We hypothesized that injecting anti-podoplanin antibody after induction of synovitis could suppress synovitis, but since podoplanin expression was decreased even after spontaneous remission by autoimmunity, it was difficult to determine the suppressive effect of anti-podoplanin antibody on synovitis.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

滑膜炎に発現するポドプラニンを抑制することができれば、関節リウマチなどの関節炎治療に応用可能と考えられる。