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2023 Fiscal Year Final Research Report

The Development of system for drug delivery to the bones using low molecular weight heparin to promote bone regeneration

Research Project

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Project/Area Number 21K09320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionGifu University

Principal Investigator

Nozawa Satoshi  岐阜大学, 大学院医学系研究科, 准教授 (20771679)

Co-Investigator(Kenkyū-buntansha) 秋山 治彦  岐阜大学, 大学院医学系研究科, 教授 (60402830)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords骨癒合 / 糖鎖 / BMP-2
Outline of Final Research Achievements

We developed a novel drug delivery system (DDS) that transports growth factors to the bone with low molecular weight heparin (LMWH) conjugated acidic peptide, which binds to hydroxyapatite (HA). Growth factors such as BMP, FGF etc. electrostatically bind to heparin. Eight mer acidic amino acids using Asp (D) bind to HA. We chemically conjugated LMWH and D8 (LMWH-D8) as a vector. Posterolateral fusion (PLF) model in which “HA is impregnated with both LMWH-D8 and BMP-2” and implanted in between transverse processes, showed significant bone formation as compared with “only BMP-2 impregnated HA”.

Free Research Field

脊椎脊髄外科

Academic Significance and Societal Importance of the Research Achievements

人口の高齢化に伴い、骨欠損部再建・脊椎固定術・人工関節置換術・偽関節治療など骨移植や早期骨癒合を必要とする状況は増加の一途を辿っている。海外では骨形成蛋白(bone morphogenic protein: BMP)が認可され、DDSとしてDemineralized Bone Matrix(DBM)・コラーゲンスポンジやゼラチンが使用されているが、局所の薬剤徐放が速いため、高用量が必要となり高価となること・創部腫脹や創治癒遅延・異所性骨化の合併症が問題点となっている。成長因子をヘパリンと一緒に骨表面まで運び骨形成を促進できるのではないかと考え研究を行っている。

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Published: 2025-01-30  

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