2023 Fiscal Year Final Research Report
The effects of filtered stem cell lysates on intestitial cystitis
| Project/Area Number |
21K09415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
堀田 祐志 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (90637563)
木村 和哲 名古屋市立大学, 医薬学総合研究院(医学), 教授 (00423848)
山本 徳則 名古屋大学, 未来社会創造機構, 特任教授 (20182636)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 間質性膀胱炎 / 脂肪由来幹細胞濾液 / 50%DMSO |
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| Outline of Final Research Achievements |
We investigated the effects of filtered adipose-derived stem cell lysate (FADSCL) using a hydrochloric acid-induced interstitial cystitis rat model. It was found that FADSCL was more effective than the existing drug, 50% DMSO intravesical administration. This study also examined the mechanism of improvement of interstitial cystitis by the treatment of FADSCL. We found that there was no significant effect on the bladder tissue itself. However, analysis of the genes in the tissue revealed that a group of genes involved in signal transduction related to the immune and inflammatory systems were moving. Although the results of this study did not lead to the identification of the active component within FADSCL for the therapeutic effect of interstitial cystitis, they did reveal one aspect of the improvement mechanism.
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| Free Research Field |
泌尿器科学
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| Academic Significance and Societal Importance of the Research Achievements |
間質性膀胱炎は、膀胱痛や頻尿症状を主訴とする難治性膀胱炎であり、難病指定されている。現在の治療は、膀胱水圧拡張術、焼灼術、50%DMSOの膀胱内投与などがあげられるが、いずれも効果は限定的であり、症状の再燃も問題となっている。本研究では、脂肪由来幹細胞濾液（FADSCL）の間質性膀胱炎への治療効果を検討した結果、FADSCLは50%DMSOよりも効果が高いことが塩酸誘発性膀胱炎モデルにより明らかになった。また改善メカニズムの一端も明らかにすることができた。これらの研究成果は、今後の間質性膀胱炎治療薬の開発の一助となることが期待される。
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