2023 Fiscal Year Final Research Report
Prevention of presbycusis by modifying cellular immune function using thymus transplantation and its application to humans
| Project/Area Number |
21K09593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Kansai Medical University |
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Principal Investigator |
SUGITA Yuki 関西医科大学, 医学部, 研究医員 (50786697)
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| Co-Investigator(Kenkyū-buntansha) |
岩井 大 関西医科大学, 医学部, 教授 (10232638)
小林 良樹 関西医科大学, 医学部, 准教授 (10375298)
稲葉 宗夫 関西医科大学, 医学部, 非常勤講師 (70115947)
神田 晃 関西医科大学, 医学部, 教授 (70375244)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 加齢性難聴 / ナイーブT細胞 / Inframmaging / 有毛細胞 / NF-κB / oxi-inflamm-aging / C57BL/6 / EGFP |
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| Outline of Final Research Achievements |
In Japan, the world's most aged society, there is an urgent need to establish preventive methods for age-related hearing loss, which may impair healthy life expectancy. Using SAMP1, a mouse model of accelerated aging that exhibits early progression of age-related hearing loss and thymic atrophy, the reporter previously demonstrated that regular intravenous injection of splenocytes from young mice of the same strain prevented the progression of age-related hearing loss. In the present study, we examined whether this phenomenon was also observed in C57BL/6 mice, and found that C57BL/6 mice were also prevented from developing age-related hearing loss, as well as from having a decreased number of hair cells and elevated NF-κB levels. Therefore, the prevention of age-related hearing loss by intravenous injection of splenocytes from young mice of the same strain is not specific to SAMP1 and is expected to be clinically applicable to humans in the future.
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| Free Research Field |
耳鼻咽喉科
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| Academic Significance and Societal Importance of the Research Achievements |
近年、抗加齢医学への関心が高まってきているが、ヒトにおける研究では長期の年月がかかるなどの理由で研究が進まず、加齢性難聴の予防法は確立していない。報告者は老化促進モデルマウスを用いて加齢性難聴予防法を研究してきたが、他の動物でも同様の結果が得られるのであれば、将来的にヒトにおいても加齢性難聴が予防できるのではないかと考える。
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