2023 Fiscal Year Final Research Report

Pathological clarification and development of novel treatment in neovascular age-related macular degeneration using adaptive-optics optical coherence tomography

Research Project

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Project/Area Number	21K09716
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56060:Ophthalmology-related
Research Institution	Kyoto University
Principal Investigator	Miyata Manabu 京都大学, 医学研究科, 講師 (00548505)
Co-Investigator(Kenkyū-buntansha)	村岡勇貴京都大学, 医学研究科, 助教 (00739089) 大音壮太郎京都大学, 医学研究科, 特定准教授 (10511850) 池田華子京都大学, 医学研究科, 特定准教授 (20372162) 三宅正裕京都大学, 医学研究科, 特定講師 (90812793)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	加齢黄斑変性 / 長期視力予後 / 組織プラスミノゲンアクチベータ / アフリベルセプト / 黄斑下血腫 / 補償光学OCT
Outline of Final Research Achievements	In neovascular age-related macular degeneration, pretreatment visual acuity correlated with visual acuity 7 years after treatment, which suggesting that early detection and early treatment are important to maintain long-term visual acuity. In submacular hemorrhage, a severe complication of neovascular age-related macular degeneration, recurrence negatively correlated with visual acuity 1 year after subretinal injection of tissue plasminogen activator. This showed that the key is how to prevent recurrence after the treatment. Adaptive optics OCT was used to examine retinal structures in detail, but it was not possible to acquire images of the retina in cases with heavy exudates or hemorrhages. In mild cases, we could obtained images, and the arrangement of Muller cells was not disrupted. Higher-performance devices are desired so that imaging can be performed in cases other than minor cases.
Free Research Field	加齢黄斑変性
Academic Significance and Societal Importance of the Research Achievements	滲出型加齢黄斑変性および視機能を脅かす最大の合併症である黄斑下血腫において、長期的に視力を維持するための方策の可能性を示すことができた。精細なイメージングが可能な補償光学を応用したAO-OCTを用いた滲出型加齢黄斑変性の病態解明の第一歩となった。本研究成果は、将来的な新規治療の礎を形成する上で重要な役割を果たすと考える。