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2023 Fiscal Year Final Research Report

Elucidation of Chronic Inflammatory Mechanisms and Development of Control Methods Focusing on Biofilm Formation on Silicon Artificial Breast

Research Project

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Project/Area Number 21K09786
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research InstitutionTohoku University

Principal Investigator

Takagi Naoyuki  東北大学, 医学系研究科, 非常勤講師 (30569471)

Co-Investigator(Kenkyū-buntansha) 菅野 恵美  東北大学, 医学系研究科, 教授 (10431595)
山口 賢次  東北大学, 医学系研究科, 非常勤講師 (70897892)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords乳房再建 / バイオフィルム / 慢性炎症 / シリコンインプラント
Outline of Final Research Achievements

In total, 113 specimens were collected from 57 cases and 58 breasts. The surface type was textured in 46 cases and smooth in 12 cases, and biofilm was detected in 31 cases in the textured group and 3 cases in the smooth group. Biofilm retention was 67% in the textured group and 25% in the smooth group, significantly higher in the textured group.The high biofilm retention rate in the textured group is likely to be one of the causes of prolonged inflammation, and a search for biofilm-forming bacteria and immunological analysis of capsular tissues may lead to a detailed elucidation of the mechanism and the development of methods to control chronic inflammation.

Free Research Field

乳房再建

Academic Significance and Societal Importance of the Research Achievements

本研究はバイオフィルム形成に焦点をあてた臨床研究であり、textured typeシリコンにおいて有意に高いバイオフィルム保有率を認めたことからも、バイオフィルムが慢性炎症を引き起こす原因の一つであることは明らかである。
今後バイオフィルムを形成する細菌叢の解析や被膜組織の免疫学的解析を進めることで、炎症遷延・慢性炎症化に関わる発生メカニズムの解明につながると予想される。それにより深刻な合併症であるこれらの合併症の予防法の樹立および生体に安全なシリコンの開発へとつながり、社会的意義は大きいものとなる。

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Published: 2025-01-30  

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