Development of innovative regenerative therapy using follicle-derived epithelial stem cells for ulcers.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Jichi Medical University
• Principal Investigator: Kinoshita Mikio 自治医科大学, 医学部, 非常勤講師 (50422308)
• Co-Investigator(Kenkyū-buntansha): 吉村 浩太郎 自治医科大学, 医学部, 教授 (60210762)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 再生医療

Outline of Final Research Achievements

In this study, we examined follicular epithelial stem cells, which are expected to have higher differentiation and proliferation potential than basal keratinocytes, the cells used in the currently cultured epidermis. The results of the rat whisker experiment indicated that follicular tissue could be regenerated in a few months, even after excision of the bulb area. This showed that hair follicle stem cells could be obtained even after excision of the bulb part of the hair follicle without destroying the collection site. However, it is essential to note that this study was conducted using rats and will require further validation.

Free Research Field

再生医療

Academic Significance and Societal Importance of the Research Achievements

培養表皮移植に用いる上皮系細胞の研究は、より能力が高い（植皮までの一時しのぎではない）ものが求められていると考えられる。本研究は、すでに確立した培養表皮化技術のうち改良の余地がある部分、能力が高い上皮系毛包幹細胞への置き換えの可能性について検証するものである。