2023 Fiscal Year Final Research Report
Is fat regeneration with bFGF-enriched PRP a reality? -Building evidence in aesthetic medicine
| Project/Area Number |
21K09802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小出 寛 順天堂大学, 大学院医学研究科, 特任教授 (70260536)
松井 千裕 順天堂大学, 医学部, 非常勤助手 (80815019)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | bFGF / PRP / 脂肪再生 / 美容医療 |
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| Outline of Final Research Achievements |
Basic fibroblast growth factor (bFGF) and platelet-rich plasma (PRP) are widely used in regenerative medicine, but adverse events from their combined transplantation have become a concern in aesthetic medicine. This study investigated the effects of bFGF-enriched PRP on adipose tissue. Human adipose tissue was injected into nude mice, followed by administration of bFGF-enriched PRP, PRP, or bFGF alone, and the effects were evaluated histologically and immunohistochemically.
The results showed: 1) bFGF-enriched PRP group promote tissue fibrosis in a bFGF concentration-dependent manner, 2) angiogenesis increased in a bFGF concentration-dependent manner and 3) PPARγ expression was higher in a bell-shaped bFGF concentration-dependent manner. Thus, low to medium concentrations of bFGF-enriched PRP promote adipocyte differentiation, whereas high concentrations enhance fibrosis.
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| Free Research Field |
形成外科学 美容外科学 再生医学
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| Academic Significance and Societal Importance of the Research Achievements |
美容医療は保険外診療が原則の為、事によれば必ずしも安全性を担保されているとは言い難いものもある。近年ではbFGF添加PRPを皮下に投与することで皮下脂肪の再生を介した組織増大を促す治療が提供されているが、多くの有害事象も報告されているなど、本治療法の安全性や有効性が科学的に検証されておらず憂慮した状況が続いてきた。今回の研究によって、bFGFの濃度次第で時に脂肪再生の促進を起こし、時に組織の線維化を惹起することが明らかとなった。本結果はbFGF添加PRP治療の脂肪組織への影響を示した初めての報告であり、美容医療領域に乏しいEBMの構築に寄与できたのではないかと考える。
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