Development of a Novel Direct Pulp Capping Material with Hard Tissue Induction and Inflammation Control Capabilities and Its Prospects for Clinical Application

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09870
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KAWASHIMA NOBUYUKI 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (60272605)
• Co-Investigator(Kenkyū-buntansha): 興地 隆史 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80204098)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 歯髄 / 歯内療法材料 / 硬組織誘導 / Bio-C sealer / Well-Root ST / EndoSequence BC sealer / S-PRG / 抗炎症

Outline of Final Research Achievements

We investigated the hard tissue induction ability of calcium silicate sealers, Bio-C sealer, Well-Root ST, and EndoSequence BC sealer. We revealed that they induced mineralized nodule formation of osteoblast-like cell line, Kusa-A1 cells in a calcium ion-dependent manner, They also promoted mRNA expression of osteopontin, one of the osteoblast markers. The same effect was also observed with a surface-reaction-type pre-reacted glass-ionomer (S-PRG) filler-containing sealer.

Free Research Field

歯内療法

Academic Significance and Societal Importance of the Research Achievements

生体傷害性を示さないだけではなく、硬組織誘導能および炎症制御能といった生物活性を有する歯内療法で使用する様々な材料が近年注目を集めている。今回現在新しく歯内療法に導入されたBio-C sealer、Well-Root ST、EndoSequence BC sealerの硬組織誘導能および炎症抑制能について検討し、どれもが硬組織誘導能および炎症抑制能を示したことから臨床においても良好な成績を示すことが期待される。また試作surface-reaction-type pre-reacted glass-ionomer filler 含有シーラーにおいても抗炎症能が示され、臨床応用が期待される。