2023 Fiscal Year Final Research Report

The mechanism of Alzheimer disease development induced by IL-1beta during occlusal disharmony

Research Project

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Project/Area Number	21K09990
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57050:Prosthodontics-related
Research Institution	Fukuoka Dental College
Principal Investigator	Kajiya Hiroshi 福岡歯科大学, 口腔歯学部, 准教授 (80177378)
Co-Investigator(Kenkyū-buntansha)	大野純福岡歯科大学, 口腔歯学部, 教授 (10152208) 都築尊福岡歯科大学, 口腔歯学部, 教授 (70330967) 前芝宗尚福岡歯科大学, 口腔歯学部, 助教 (90964338)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	アルツハイマー型認知症 / 咬合不調和 / 軽度認知障害 / アミロイドβ / リン酸化タウ
Outline of Final Research Achievements	It has been reported that occlusal disharmony also affects the release of neurotransmitters in the central nervous system. However, it is unclear how occlusal disharmony affects cognitive ability. We investigated how occlusal disharmony affects cognitive ability and whether it is involved in the expression of dementia-inducing substances using Alzheimer's disease (AD) model mice. Excessive occlusal load transiently reduced the cognitive ability of 2-month-old AD model mice, and at the same time, sustained an increase in the expression of molecules related to the initiation of AD. At the same time, the expression of amyloid beta excretion molecules transiently increased. From the above, it was thought that occlusal disharmony could be a risk factor for inducing the onset of AD.
Free Research Field	細胞分子生物学
Academic Significance and Societal Importance of the Research Achievements	現在の超高齢者社会ではオーラルフレイル進行を防止し、口腔の健康寿命を保持し、全身の健康寿命を最大限に維持するかが社会的に重要な課題である。我々は、「調和のとれた咬合機能がどの様な分子メカニズムで認知能の正常化維持に関わり、全身の健康寿命の保持を導くか明らかにする」をこと目標とし、研究を継続してきた。本課題の結果は、過剰咬合による咬合不調和状態であるとアルツハイマー発症誘発物質の発現増加を伴って、認知症の発症リスクが増大することが明らかした。従って、口腔の健康寿命の維持ために調和のとれた咬合支持の重要性が科学的に実証でき、社会に発信・啓蒙できる学術的な結果が得られたと考えている。