Basic research for development of prevention and treatment methods for root resorption applying bFGF

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Kuroishi Kayoko (中尾加代子) 九州歯科大学, 歯学部, 助教 (60468303)
• Co-Investigator(Kenkyū-buntansha): 森井 葵 九州歯科大学, 歯学部, 医員 (20882046) ; 左合 美紗 九州歯科大学, 歯学部, 特別研修員 (40815825) ; 川元 龍夫 九州歯科大学, 歯学部, 教授 (50323704) ; 水原 正博 九州歯科大学, 歯学部, 助教 (60845402) ; 郡司掛 香織 九州歯科大学, 歯学部, 講師 (90448811)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 歯根吸収 / メカニカルストレス / CEMP1 / CAP / FGF2（ｂFGF）

Outline of Final Research Achievements

We investigated the effect of mechanical stimulation on human periodontal ligament cells and the expression kinetics of cementoblast differentiation factors, CEMP1 and CAP, focusing on basic fibroblast growth factor, bFGF (FGF-2), in order to clarify the mechanism of root resorption in orthodontic treatment. CEMP1 mRNA was not changed by mechanical stimulation, but was significantly increased by addition of bFGF. CAP and FGF-2 receptor FGFR1 mRNA was significantly increased by mechanical stimulation and addition of bFGF. FGF-2 is involved in cementoblast differentiation factor CEMP1 and CAP expression in mechanically stimulated human periodontal ligament cells, suggesting that FGF-2 may be involved in the developmental mechanism of root resorption.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

本研究により矯正歯科治療に伴う歯根吸収発症機序を学術的に明らかにし、矯正学的歯の移動により生じた歯根吸収の予防法そして吸収した歯根の再生方法を開発し、歯根吸収の治療法が確立できれば、嚢胞や埋伏歯等により生じた重度歯根吸収にも応用し、抜歯を回避し歯の長期保存の可能性や治療の選択肢が拡大することが期待され社会的有用性があると考える。